Nimodipine is a calcium antagonist of the dihydropyridine group.
It's classified as a vasodilator and hypotensive medicine.


For the reduction of cerebral infarction and improvement of outcome after sub-arachnoid haemorrhage.

Safety in pregnancy and lactation has not been established.


Management of overdose:
Symptoms: Hypotension, tachycardia ...also see "side-effects"
Rx: Symptomatic and supportive.


Decrease in blood pressure, slight increase or decrease in heart rate, sweating, dizziness, flushing, headache, gastro-intestinal disorders, nausea and the feeling of warmth.
A transient rise in liver enzymes may occur during I/V administration, this usually reverts to normal on completion of treatment.
Thrombocytopaenia and ileus have been reported rarely.


Use with care when cerebral oedema or severely raised intracranial pressure are present.
May potentiate hypotensive effect of antihypertensives.
Concomitant administration of calcium antagonists, alpha-methyl-dopa or beta-blockers should be avoided. Where such co-administration is unavoidable, careful dose titration of nimodipine should be undertaken with possible reduction or discontinuation of the antihypertensive agent.
Caution is required in patients with systolic blood pressure < 90mmHg.
Blood levels of nimodipine may be increased with concomitant administration of cimetidine or anticonvulsant sodium valproate. In patients treated with enzyme inducing anti-convulsants such as phenytoin, phenobarbital and carbamazepine, the plasma concentrations of nimodipine may be markedly reduced.
Patients with known renal disease and/or recieving nephrotoxic drugs, should have renal function monitored closely during I/V treatment.
In patients with severely impaired liver function, dosage reduction may be required.

Safety in pregnancy and lactation has not been established.


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