About Using Zyprexa for Depression


Once depression has been diagnosed, patients need to work with a healthcare practitioner to identify a treatment pathway that works best for them.

What’s important to know is that there are effective treatments for depression, which may include a prescription medication, a combination of more than one prescription medication and/or talk therapy.

One prescription medication that a doctor may prescribe is Zyprexa (olanzapine).

Medication Class

Zyprexa is a second generation antipsychotic medication, which is a type of medication used to treat psychiatric conditions such as depression, schizophrenia, acute mania, bipolar disorder and bipolar mania. Zyprexa is also referred to as an "atypical" antipsychotic because it does not cause the same degree of movement side effects that are common with "typical" or first generation antipsychotics.


Zyprexa has been approved by the U.S. Food and Drug Administration (FDA) for several uses including:

  • • episodes of depression that happen with bipolar I disorder, when used with the medicine
    fluoxetine (Prozac) in people age 10 or older
  • • episodes of depression that do not get better after two other medicines, also called treatment-resistant depression, when used with the medicine fluoxetine (Prozac) in adults
  • • schizophrenia in people age 13 or older
  • bipolar I, including: 1) manic or mixed episodes that happen with bipolar I disorder in people age 13 or older; 2) manic or mixed episodes that happen with bipolar I disorder, when used with the medicine lithium or valproate, in adults; and 3) long-term treatment of bipolar I disorder in adults

Zyprexa is not approved for use in children younger than 13 years old. Additionally, the combination of Zyprexa and Prozac has not been approved for use in children younger than 10 years old.


Zyprexa is available in tablets (2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg), orally disintegrating tablets (5 mg, 10 mg, 15 mg, 20 mg) and as an injection (10 mg vial).

Side Effects

Zyprexa can cause serious side effects in some people including suicide and death. Other side effects may include dizziness, stomach pain, dry mouth, constipation, weight gain and drowsiness.
Like any medication, it’s important to talk to a physician to determine the best way to take Zyprexa and to report any bothersome side effects.

Source: Zyprexa Product Information and Zyprexa Medication Guide


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