How to Treat Depression with Bupropion


Are you unhappy with your current prescription treatment for depression?

It’s important to know that you are not alone, as this happens to many people with depression. Some people need to try several types of antidepressants before finding one that works best for them.

While there are many reasons why you may be unhappy and want to change depression medication, it is extremely important to keep taking your current medication as prescribed until you speak to a doctor. One medication that you may want to ask your doctor about is bupropion, which is better known by its brand name, Wellbutrin.

Medication Class

Wellbutrin, with a generic name of bupropion hydrochloride, is an antidepressant of the aminoketone class, which is chemically unrelated to tricyclics, tetracyclics, selective serotonin reuptake inhibitors, or other known antidepressant therapies.


Wellbutrin has been approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder. It is only approved for use in adults aged 18 years and older.

Wellbutrin is also available in a sustained-release formulation called Wellbutrin SR and an extended-release formulation called Wellbutrin XL. The extended-release version – Wellbutrin XL – is approved to treat seasonal affective disorder (SAD).

Wellbutrin also is available under a different brand name – Zyban – which is used to help people stop smoking. People who use Wellbutrin for depression should not use Zyban at the same time.


Wellbutrin is available as a 75 mg and 100 mg coated tablet. The usual dose for adults is 300 mg per day, which is generally given as three 100 mg tablets. However, new Wellbutrin patients should start at 200 mg per day, given as two 100 mg tablets.

Side Effects

Wellbutrin can cause side effects in some people, such as seizures, weight loss, dry mouth, nausea, difficulty sleeping, dizziness, sore throat, constipation or flatulence.

Like any medication, before you start using Wellbutrin, it’s very important to speak with your doctor about the proper way to take the medication and to be aware of any potential side effects.


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