How to Treat Depression with Zoloft


Treatment options for depression may include a prescription antidepressant medication, a combination of more than one prescription medication such as an antidepressant and an anti-anxiety medication, and/or psychotherapy, which is commonly referred to as "talk therapy."

One prescription medication that a doctor may prescribe is an antidepressant medication called Zoloft (sertraline HCI).

Like any medication, before you start using Zoloft, it’s very important that you speak with your doctor about the proper way to take the medication and be aware of any potential side effects.

Medication Class

Zoloft belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). These medications target and work on a chemical in the brain called serotonin, which helps regulate moods.

Conditions Zoloft Treats

Zoloft has been approved by the U.S. Food and Drug Administration (FDA) to treat six different mental illnesses in adults:

  1. Major Depressive Disorder (MDD)
  2. Obsessive-Compulsive Disorder (OCD)
  3. Panic Disorder
  4. Posttraumatic Stress Disorder (PTSD)
  5. Premenstrual Dysphoric Disorder (PMDD)
  6. Social Anxiety Disorder

There is only one condition that Zoloft is approved to treat in children: obsessive-compulsive disorder. It is not approved to treat children under the age of 6.


Zoloft is available in tablet form and in three different doses: 25 mg, 50 mg and 100 mg.

Adverse Effects

Like any medication, Zoloft can cause side effects in some people. Antidepressant medications such as Zoloft may increase suicidal thoughts or actions in some people, especially within the first few months of treatment.

Patients should not take Zoloft if they take a monoamine oxidase inhibitor (MAOI) or have stopped taking this type of medication within two weeks.

The most commonly observed side effects in patients treated with Zoloft include nausea, delayed ejaculation, shakiness, increased sweating, lack of appetite and reduced sexual desire.



The information provided on the is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.

Sign up for our newsletter to receive mental health Information & Inspiration


PsyWeb Poll

Are you currently taking or have you ever been prescribed anti-depressants?: