Treat Depression with Zoloft


If you have been diagnosed with depression, your doctor may prescribe an antidepressant medication called Zoloft (sertraline HCI). Like any medication, before you start using Zoloft, it’s very important that you speak with your doctor about the proper way to take the medication as well as learn about any potential side effects.

Here are some important things you should be aware of about Zoloft:

Type of Medication

Zoloft belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). SSRIs work on a chemical in the brain called serotonin, which helps regulate people’s moods.


An indication is another way of stating what a drug has been approved to treat by the U.S. Food and Drug Administration (FDA). Zoloft has been FDA-approved to treat six different types of conditions in adults, including:

  • Major Depressive Disorder (MDD)
  • • Obsessive-Compulsive Disorder (OCD)
  • • Panic Disorder
  • • Post-Traumatic Stress Disorder (PTSD)
  • • Premenstrual Dysphoric Disorder (PMDD)
  • • Social Anxiety Disorder (SAD)

Zoloft is also FDA-approved to treat Obsessive-Compulsive Disorder (OCD) in children ages six to 17.


Zoloft is a tablet that is available in several doses: 25mg, 50mg and 100mg. A patient should discuss the appropriate dosage with his or her doctor.

Potential Side Effects

Antidepressant medications such as Zoloft may increase suicidal thoughts or actions in some people, especially within the first few months of treatment. Patients also should not take Zoloft if they take a monoamine oxidase inhibitor (MAOI) or have stopped taking this type of medication within two weeks.

The most commonly observed side effects in patients treated with Zoloft include nausea, delayed ejaculation, shakiness, increased sweating, lack of appetite and reduced sexual desire.

Open Dialogue with Doctor

Remember when you are on medication to treat depression, it’s important that you keep an open dialogue with your doctor about how you are feeling and any side effects you experience. One medication may not work, but another might. It’s important not to give up on treating your depression.



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