Safety of First-Generation Antipsychotics Like Haloperidol

First-generation antipsychotics (typical antipsychotics, neuroleptics) have been around since the 1950s, but how safe are first-generation antipsychotics like haloperidol? One doctor, Henry A. Nasrallah, MD, suggests that haloperidol and its likenesses should be retired as first generation antipsychotics are not safe for the brain (he and the literature contend). Are first-generation antipsychotics like haloperidol safe or possibly neurotoxic?


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