Bupropion ( Wellbutrin )

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Bupropion ( Amfebutamone, Wellbutrin )

Interactions

Name / Class

Effect of Interaction

Antidepressants
( Tricyclics ):

  • 1. ALL

Increase risk of having major seizures

Carbamazepine.

May increase the effects of Carbamazepine
Increase risk of having seizures

Cimetidine.

May increase bupropion effects

Clozapine.

Increase risk of having major seizures

Fluoxetine.

Increase risk of having major seizures

Haloperidol.

Increase risk of having major seizures

Levodopa.

May increase the effects of Levodopa
Increase risk of having seizures

Lithium.

Increase risk of having major seizures

Loxapine.

Increase risk of having major seizures

Molindone.

Increase risk of having major seizures

Monoamine Oxidase Inhibitors
( MAO ):

  • 1. ALL

May increase bupropion levels
( Bupropion Toxicity )

Phenothiazines:

  • 1. ALL

Increase risk of having major seizures

Phenytoin.

May increase the effects of Phenytoin
Increase risk of having seizures

Thioxanthenes:

  • 1. ALL

Increase risk of having major seizures

Trazodone.

Increase risk of having major seizures

How it works:
Increases the levels of norepinphrine and dopamine and is primarily a stimulant to brain activity.

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