Sponsored Links

Buspirone ( BuSpar )

Buspirone ( BuSpar )

Buspirone ( BuSpar ) is an Antianxiety agent, used primarily for relief of mild to moderate anxiety and nervous tension. This drug is useful in treating the elderly,alcoholics,or people that have a history of addiction.Alcohol does not interact in a dangerous manner with Buspirone( BuSpar ) and Buspirone ( BuSpar ) may be useful in reducing alcohol craving. This drug is also useful in the treatment of aggression in developmentally disabled persons over 18 or self-injurious behaviors.Buspirone( BuSpar ) may also be useful in treating hyperactivity in the autistic and may decrease the symptoms of obsessive-compulsive disorder ( OCD. ) It may also help in people with aches,cramps,fatigue,pains,PMS,or sexual dysfunction do to generalized anxiety disorder.Buspirone( BuSpar ) may help decrease the urge for nicotine.Buspirone ( BuSpar ) is not habit-forming.Buspirone ( BuSpar ) is not a benzodiazepine.Buspirone HCL is indicated for the management of anxiety disorders or the short-term relief of anxiety. It is the generic form of BuSpar.

The mechanism of action of BUSPAR is not clearly known. BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with benzodiazepines

In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). BUSPAR has no significant affinity for benzodiazepine receptors in the brain.


Azaspirodecanedione Derivative.

Generic name:

Buspirone Hydrochloride.




Buspirone Hydrochloride is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. It is an agent that is not chemically or pharmacologically related to the benzodiazepines (e.g. Valium, Xanax) barbituates, or other sedative/anti-anxiety drugs.

Buspirone tablets come in 5mg, 10mg, 15mg and 30mg strengths.

Call to Speak to a Specialist

Call 1-877-398-2002 Anytime To Discuss Treatment Options if you or a loved one is struggling with mental health issues.

The recommended initial dose is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maximum daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.

The excellent efficacy of BUSPAR has been demonstrated in controlled clinical trials of outpatients with a diagnosis of Generalized Anxiety Disorder (GAD).

The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months. Generalized, persistent anxiety (of at least one month continual duration), manifested by symptoms from three of the four following categories :

Motor tension: Shakiness, jitteriness, jumpiness, trembling, tension, muscle aches, fatigability, inability to relax, eyelid twitch, furrowed brow, strained face, fidgeting, restlessness, easy startle.

Autonomic hyperactivity: Sweating, heart pounding or racing, cold, clammy hands, dry mouth, dizziness, lightheadedness, paresthesias (tingling in hands or feet), upset stomach, hot or cold spells, frequent urination, diarrhea, discomfort in the pit of the stomach, lump in the throat, flushing, pallor, high resting pulse and respiration rate.

Apprehensive expectation: Anxiety, worry, fear, rumination, and anticipation of misfortune to self or others.

Vigilance and scanning: Hyper-attentiveness resulting in distractibility, difficulty in concentrating, insomnia, feeling "on edge", irritability, impatience.

The effectiveness of BUSPAR in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials. There is no body of evidence available that systematically addresses the appropriate duration of treatment for GAD. However, in a study of long-term use, 264 patients were treated with BUSPAR for 1 year without ill effect. Therefore, the physician who elects to use BUSPAR for extended periods should periodically reassess the usefulness of the drug for the individual patient.


The more commonly observed untoward events associated with the use of BUSPAR not seen at an equivalent incidence among placebo-treated patients include dizziness, nausea, headache, nervousness, lightheadedness, and excitement.

Other common adverse events included: central nervous system disturbances (3.4%), primarily dizziness, insomnia, nervousness, drowsiness, and lightheaded feeling; gastrointestinal disturbances (1.2%), primarily nausea; and miscellaneous disturbances (1.1%), primarily headache and fatigue.

Interference with cognitive and motor performance: Studies indicate that BUSPAR is less sedating than other anti-anxiety medications and that it does not produce significant functional impairment. However, its CNS effects in any individual patient may not be predictable.

Therefore, patients should be cautioned about operating an automobile or using complex machinery until they are reasonably certain that BUSPAR treatment does not affect them adversely.

While formal studies of the interaction of BUSPAR with alcohol indicate that BUSPAR does not increase alcohol-induced impairment in motor and mental performance, it is prudent to avoid concomitant use of alcohol and BUSPAR.

In human and animal studies, BUSPAR has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers with a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between BUSPAR and placebo. In addition, studies in monkeys, mice, and rats have indicated that BUSPAR lacks potential for abuse.

Although there is no direct evidence that BUSPAR causes physical dependence or drug-seeking behavior, it is difficult to predict from experiments the extent to which a CNS-active drug will be misused

[1] [2] Previous Page

More Information


Need Help? A Counselor is Waiting

All Sessions Start for Free - Click below to get started


Sponsored Links

Related Articles

  • addiction news thumbnailMarinol, also known as Dronabinol is a form of cannabis – much like marijuana. Its main function is impacting the central-nervous system and is often used in the same manner that medical marijuana…
  • addiction news thumbnailUltram is a brand of tramadol which is a generic analgesic. Typically, Ultram and treatments like it are prescribed in efforts to help cope with pain. Before committing to Ultram, however, it is imp…
  • addiction news thumbnailChronic pain and depression are a perverse combination of physical and mental conditions, but nevertheless are fairly common. As tiresome and annoying as chronic, non-stop pain can be, when it is coup…

Treatment Options

Call to Speak to a Specialist

Call 1-877-398-2002 Anytime To Discuss Treatment Options if you or a loved one is struggling with mental health issues.

Find a Treatment Center

To search by State and City instead of by Zip Code / Postal Code, select a state from the list below.

Select a State Below


Support Groups


For individuals, friends and families who are looking to connect during life's challenging times. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.


The information provided on the PsyWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of PsyWeb.com nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.

Need Help? A Counselor is Waiting

All Sessions Start for Free


PsyWeb Poll

Are you currently taking or have you ever been prescribed anti-depressants?:

Sponsored Links


visit SupportGroups.com

SupportGroups.com provides a support network for those dealing with mental health and other life's challenges. Click on the following links to get the support in a confidential, caring environment.