Celexa® (Citalopram hydrobromide) is used to treat major depression. It is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs).

Serotonin is a neurotransmitter that carries messages over the gap (synapse) between nerve cells. SSRIs increase the amount of serotonin that remains in the gaps (synapses).

Normally, serotonin, a neurotransmitter, is released and taken back in by presynaptic cells. SSRIs inhibit the "reuptake" of serotonin which floods the areas between synapses with serotonin. This results in decreased serotonin production, but a higher ratio of serotonin to serotonin receptors in the synapses. The brain, over time, takes time to adapt to this situation which is why antidepressants take a few weeks to take effect and why at first they often cause increased anxiety.

Available Dosages:

Tablets:10mg, 20 mg, 40 mg.

Full Benefits In:

Several months.


Celexa (Citalopram) should not be taken during treatment with escitalopram (Lexapro). Also, if you have had an allergic reaction to escitalopram (Lexapro), you may also have an allergic reaction to citalopram.

Do not take citalopram without first talking to your doctor if you have had an allergic reaction to either medication in the past.

Celexa (Citalopram) is in the FDA pregnancy category C. This means that it is not known whether Celexa (Citalopram) will be harmful to an unborn baby.

Do not take Celexa (Citalopram) without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Celexa (Citalopram) passes into breast milk and may affect a nursing infant. Do not take Celexa (Citalopram) without first talking to your doctor if you are breast-feeding a baby..

Celexa Side Effects

Common: Abdominal pain, agitation, anxiety,diarrhea, drowsiness, dry mouth, ejaculation disorders, fatigue, impotence, indigestion, insomnia, loss of appetite, nausea, painful menstruation, respiratory tract infection, sinus or inflammation, sweating, tremor, and / or, vomiting.

Less Common: Amnesia, attempted suicide, confusion, coughing, decreased sexual drive, depression, excessive urination, fever, gas, impaired concentration, increased appetite, increased salivation, itching, joint pain, lack of emotion, loss of menstruation, low blood pressure, migraine, muscle pain, rapid heartbeat, rash, skin tingling, taste disturbances, visual disturbances, weight gain, weight loss, yawning

Rare: Abnormal dreams, acne, aggressive behavior, alcohol intolerance, angina (chest pain), arthritis, belching, bone pain, breast enlargement, breast pain, bronchitis, bruising, chills, conjunctivitis (pinkeye), decreased muscle movements, delusions, dermatitis, difficulty breathing, difficulty swallowing, dizziness, drug dependence, dry eyes, dry skin, eczema, emotional instability, excessive milk flow, excessive muscle tone, eye pain, fainting, feeling of well-being, flu-like symptoms, flushing, frequent urination, gum inflammation, hair loss, hallucinations, heart attack, heart failure, hemorrhoids, high blood pressure, hives, hot flashes, inability to hold urine, inability to urinate completely, increased sex> drive, increased urination, involuntary muscle movements, leg cramps, mouth sores, muscle weakness, nosebleeds, numbness, painful erection, painful urination, panic, paranoia, pneumonia, psoriasis, psychosis, ringing in the ears, sensitivity to light, skin discoloration, slow heartbeat, stomach and intestinal inflammation, stroke, swelling, teeth grinding, thirst, uncontrollable muscle movements, unsteady or abnormal walk, vaginal bleeding.

See physician always: An allergic reaction (difficulty breathing; closing of the throat, swelling of the lips, tongue, or face, or hives), an irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), or chills or fever.

See physician if severe: Headache, tremor, nervousness, anxiety, nausea, diarrhea, dry mouth, or changes in appetite or weight, sleepiness or insomnia, decreased sex drive, impotence, or difficulty having an orgasm.

See physician NOW: An allergic reaction (difficulty breathing; closing of the throat, swelling of the lips, tongue, or face, or hives), an irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), or chills or fever.

Celexa (Citalopram) Interactions

  • Any monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. A dangerous drug interaction can occur when citalopram is combined with any of these medications.
  • Any antidepressant such as fluoxetine (Prozac), fluvoxamine (Luvox), sertraline (Zoloft), paroxetine (Paxil), trazodone (Desyrel), or nefazodone (Serzone).
  • Any tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor).
  • Any antiseizure medication including carbamazepine (Tegretol) or felbamate (Felbatol).
  • Any stomach medicine such as cimetidine (Tagamet, Tagamet HB), ranitidine (Zantac, Zantac 75), or omeprazole (Prilosec).
  • Any antibiotic such as erythromycin (Eryc-Tab, E-Mycin, E.E.S., Erythrocin, P.C.E., others) or clarithromycin (Biaxin).
  • Any antifungal medication such as fluconazole (Diflucan), itraconazole (Sporano x), or ketoconazole (Nizoral).
  • Any migraine medication such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig).
  • Asthma medication zafirlukast (Accolate) or lithium (Eskalith, Lithobid, Lithonate, Lithotabs).


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