Disorders and Treatment
- Mental Illness
- Bipolar Disorder
- Mood Disorders
- Borderline Personality
- Mental Health Diagnosis
- Mental Health Treatments
- Alternative Meds
- Case Studies
Isocarboxazid ( Marplan ) is used for the treatment of clinical depression. It is usually given after other medicines have failed to help. Isocarboxazid ( Marplan ) increases chemicals in the brain. The low levels of these chemicals may have caused the depression. Sleep and appetite may improve quickly. Other symptoms may take up to 4-6 weeks to improve.
Isocarboxazid ( Marplan ) is superior to placebo on depression, anxiety, interpersonal sensitivity, and global measures, and on symptoms of hostility, anxiety, obsessiveness, and psychological-cognitive components of depression. There were no significant differences between treatment effects on psychomotor and typical vegetative symptoms. Isocarboxazid was more effective than placebo in major, but not in minor, depression. It was significantly more effective in depression classified as endogenous depression or melancholia by various diagnostic criteria. Isocarboxazid ( Marplan ) was more effective than placebo in atypical depression with vegetative reversal and in Brief Psychiatric Rating Scale (BPRS)-derived profiles of anxious and hostile depression.
|CLASS:||Monoamine Oxidase Inhibitor|
Liver Function: Carefully monitored.
Kidney Function: N/A.
Before taking: None.
While taking: None.
Full Benefits In: One or six weeks.
Missed Dose(s): If within one hour take, if over an hour skip and then continue on your normal schedule.
Never Take a Double Dose.
If Stop Taking: Do not stop without consulting your physician and never abruptly.
Overdose symptoms include: severe anxiety, confusion, convulsions, cool clammy skin, severe dizziness, severe drowsiness, fast and irregular pulse, fever, hallucinations, severe headache, high or low blood pressure, hyperactive reflexes, muscle stiffness, respiratory depression or failure, slowed reflexes, sweating, severe trouble in sleeping, and unusual irritability.
Isocarboxazid should not be started until one or two weeks after a TCA or related antidepressant or SSRI or related antidepressant has been stopped ( 5 weeks for fluoxetine ). Any other antidepressant, or another MAOI, should not be started for one or two weeks after isocarboxazid has been stopped
Stay away from tyramine-containing foods and drinks. Examples of foods to avoid are:
Talk with healthcare provider and nutritionist for more education.
Check blood pressure regularly.
Follow diet plan as recommended by healthcare provider. No tyramine-containing products.
Do not take a double dose or extra doses.
Do not change dose or stop taking medicine without talking with healthcare provider.
Avoid alcohol intake (includes wine, beer, and liquor ). Can cause life-threatening high blood pressure even 2 weeks after medicine is stopped.
Limit caffeine ( e.g., tea, coffee, cola ) and chocolate intake.
Do not use over-the-counter products that may affect blood pressure. These include cough or cold remedies, diet pills, stimulants, ibuprofen or like products, and certain herbs or supplements. Talk with healthcare provider.
Do not use over-the-counter medicines containing dextromethorphan ( Robitussin-DM
The information provided on the PsyWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of PsyWeb.com nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.