Romazicon( flumazenil ) data sheet

romazicon

Romazicon, also known as Flumazenil, Anexate, Lanexat and Mazicon is the only benzodiazepine antagonist available on the market today. First approved by the FDA, it comes in injectable form only and has been found to be beneficial for people who get overly drowsy using other benzodiazepines. It has also been given successfully as an antidote for benzodiazepine overdoses.

Romazicon is fast acting and works by reversing or inhibiting the sedatory, psychomotor and recall impairment as well as respiratory depression effects of benzodiazepines. This is accomplished by antagonizing the effects of benzodiazepines on the central nervous system. More specifically the activity of the benzodiazepines at the recognition site on the GABA/benzodiazepine receptor complex is completely inhibited. Romazicon does not reverse the effects of opioids or inhibit the central nervous system effects of barbiturates, ethanol or general anesthetics.

Some people who take Romazicon may experience side effects that include:

  • Changes in vision including blurry vision.
  • Dizziness
  • Dry mouth
  • Clumsiness
  • Hot flashes
  • Abnormal skin sensations
  • Headache
  • Intense sweating
  • Nausea/vomiting
  • Feeling a whirling motion
  • Infection at injection site
  • Flushing
  • Body discomfort
  • Nervousness
  • Restlessness
  • Tremors
  • Problems with sleep
  • Weakness
  • Difficulty breathing
  • Rapid heartbeat or breathing
  • Agitation
  • Change in mood or behavior
  • Rash
  • Pounding in chest
  • Swelling of mouth, tongue or throat
  • Seizures
  • Anxiety/depression

Anyone experiencing any of these side effects should consult with their health care provider. Some side effects may be very serious and should be treated by a doctor immediately.

Contraindications

Romazicon may be contraindicated with certain medical conditions. Anyone who is taking Romazicon or considering taking it should consult their health care provider if they have any medical condition especially the following:

  • Epilepsy
  • Liver disease or issues
  • History of head injury
  • Anxiety
  • Panic disorder
  • Heart disease
  • Nerve function issues
  • Benzodiazepine abuse

If you are unsure about possible interactions with Romazicon, please discuss concerns with your health care provider.

 
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