Clorazepate ( Tranxene ) data sheet


Clorazepate is a benzodiazepine and is marketed under the names Tranxene and Novo-Clopate. It contains anxiolytic, anticonvulsant, hypnotic, sedative and muscle relaxant properties and is used to treat anxiety, insomnia, certain forms of seizures and symptoms of alcohol withdrawal. Clorazepate comes in tablet form and is taken orally usually between 2-4 times per day.

Clorazepate side effects

Like all medications, Clorazepate has potential side effects. Anyone taking Clorazepate should be aware of possible side effects and contact their health care provider if they experience any of the following:

  • Dizziness
  • Drowsiness
  • Fatigue/tiredness
  • Headache
  • Confusion
  • Nervousness
  • Dry mouth
  • Uncontrollable shaking or tremor in a part of the body
  • Blurry or double vision
  • Slurred speech
  • Balance issues
  • Rash

Clorazepate contraindications

Before taking Clorazepate, patients should be aware of possible adverse effects with other medications or substances as well as possible medical conditions that would rule them out as a candidate for this medication. Some things that may cause adverse reactions or be contraindicated with Clorazepate include:

  • Other medications, vitamins or herbal products
  • Kidney disease
  • Liver disease
  • History of illegal drug use
  • Depression
  • Tobacco
  • Glaucoma
  • Impending surgery including dental surgery

If you are pregnant, breastfeeding or considering pregnancy do not take Clorazepate without discussing it with your doctor. If you become pregnant while taking Clorazepate call your doctor immediately.

Persons 65 and older may not be a candidate for Clorazepate.

One of the most important issues related to Clorazepate is its ability to change people’s mood or mental health in unpredictable ways. Some people taking Clorazepate have worsening depression, thoughts of suicide of hurting themselves, increased aggression, angry, violent behavior, mania or preoccupation with death. If anyone experiences any of these feelings or thoughts they should seek the care of a health care professional immediately.

People taking Clorazepate may develop an addiction to it and suffer withdrawal symptoms if they do not take it or stop taking it suddenly. Anyone wishing to stop taking Clorazepate should do so only under the care of a doctor.


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